Generating Better Preclinical Research Models: Approaches & Considerations

With recent advancements in mouse model generation technologies, researchers can now develop more precise models with greater efficiency, reduced time, and lower costs. However, the increasing array of available methodologies presents challenges in selecting the most appropriate strategy to align with specific research objectives. In this presentation, we will systematically discuss key model development considerations, including how to define research goals, select an optimal genetic background, and determine appropriate downstream applications for founder mice.