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Selecting and Using Mouse Models in Neurodevelopmental Drug Discovery

Published Date

Join the JAX In Vivo Services team as they share insights from extensive neurobiology drug discovery studies conducted for both academic and commercial clients. This webinar will cover the underlying biology of various neurodevelopmental mouse models, the translatability of their phenotypes, and optimized usage for producing clinically predictive data for drug development.

Topics include:

  • Natural history and phenotypes of mouse models of Angelman, CDKL5, Rett, and Dravet syndromes and more
  • Crucial phenotypic characteristics for selecting therapeutically relevant models
  • Sample study designs and experimental readouts for assessing molecule efficacy in treating neurodevelopmental diseases

Timestamps:

11:40 - Rett Syndrome 

18:36 - Angelman Syndrome

23:12 - SHANK3 Deletion Syndrome

26:01 - Cdkl5 Deficiency Disorder 

30:55 - Dravet Syndrome 

36:25 - Krabbe Disease

40:00 - Niemann-Pick Disease 

45:32 - Pompe Disease 

Search JAX's Mouse Model Repository.