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Immune-Humanized PDX Model-Estrogen-Independent, Hormone Receptor-Positive Metastatic Breast Cancer

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The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatment options. Sandra D. Scherer, Ph.D. describes the development of an immune-humanized PDX model of estrogen-independent endocrine-resistant ER+ MBC.